Del Negro was the youngest of three children growing up in Mount Kisco, NY. He graduated from Boston College where he played Division 1 lacrosse.
After graduating, Del Negro began to study acting, gaining appearances in independent films and commercials.
He has mainly made appearances on crime shows such as Law and Order, CSI: Miami, The Sopranos, and NCIS. His most recent roles include Jacob Pollock on Mistresses and Michael on Scandal.
He also provided his voice to several videogames like SOCOM 4: U.S. Navy Seals, L.A. Noire, and Mass Effect 3.