Ponzio is part Sicilian, part Native American and part French.
She started performing at a young age, spending much of her childhood impersonating members of her family for laughs.
She credits a late night viewing of the movie Alien with her choice to pursue an acting career.
Ponzio studied theater at Georgia State University and worked for 3 years as a News Assignment Editor for an Atlanta area TV Station before quitting to work full time as an actor.
She found success first in commercials and was featured in more than one hundred regional and national advertisements.
In 2013, Ponzio appeared as a guest star on AMC's The Walking Dead.
Ponzio is a co-owner of The Goods, Inc, a comedy and entertainment group based in Atlanta.