Ploszek was born in Hinsdale, Illinois but grew up across New Jersey, Maine, and Ohio before his family returning to Illinois in 1998.
As a football player at St. Charles East High School, he earned many accolades. In 2009, he graduated from Princeton University, where he was a four-year member of the Princeton Tigers football team. He graduated with a MFA in Acting from the USC School of Dramatic Arts in 2012.
Only recently starting his acting career, Ploszek got his first role in 2012 with the short film Outrage: WME.
His most notable role to date is portraying Leonardo in the 2014 live action reboot of Teenage Mutant Ninja Turtles. He portrayed the character through motion-capture but was dubbed by Johnny Knoxville without knowing it. In the 2016 sequel, Teenage Mutant Ninja Turtles: Out of the Shadows, he got to voice the character.
He made a few appearances in some television shows like Parks and Recreation, Shameless, TakePart Live, and Workaholics.
In 2016, he published a book called "Get Fast and Crush the Combine" which has been called a guide for high school athletes.